Zoloft Side Effects First Week

Zoloft Side Effects First Week | Zoloft (sertraline) is a type of medicine which is called selective serotonin reuptake inhibitors, or SSRIs. These medications work by increasing the level of serotonin in the brain.

zoloft side effects first week

Starting Zoloft: Possible side effects of Zoloft

It’s important that you don’t expect immediate results when taking Zoloft. People typically notice some improvement within a week or two, but it may take several weeks until you feel the full effects of the drug.

Also, when you start taking Zoloft, you may experience some side effects. The commonest ones include nausea or upset abdomen, diarrhea, sweating, tremor, or a decreased urge for food. May affect your sexually, most notably ejaculation failure and decreased libido.

If any of these the side effects don’t go away or are giving you significant problems, be sure to contact your doctor. Generally, easy treatments can ease the unintended effects of taking Zoloft like taking it at a distinct time of day or altering the dose. Other times, if the side effects are too bothersome, your doctor may recommend switching to a different SSRI or a different class of medication altogether.

Common Side Effects:

  • Nausea
  • Diarrhea
  • Sweating
  • Tremor
  • Ejaculation failure
  • Decreased libido
  • Decreased appetite
  • Suicidal Thoughts and Behavior
  • Serotonin syndrome
  • Bleeding risk with blood thinners
  • Mania or hypomania with bipolar disorder
  • Low sodium levels
  • Allergic reaction (rare)
  • The risk in pregnancy of infant developing persistent pulmonary hypertension

Serious Side Effects:

Along with the common side effects we talked about before, there are some serious side effect to be looked out if you’re taking Zoloft.

Suicidal Thoughts and Behavior

A “black-box-warning” refers to a serious notice made by the U.S. FDA (Food and Drug Administration) about this medication.

The black-box warning for Zoloft indicates it may cause or increase thoughts of suicide in children and young adults.

Monitor your loved one, or yourself if you’re in this age group, for any signs of such thoughts, and contact your doctor immediately if they occur.

Serotonin Syndrome

Taking Zoloft may put you at risk of a life-threatening condition called serotonin syndrome.

This threat is greater if an individual is also taking different serotonin-related medicines like triptans (a typical migraine medicine), tricyclic antidepressants, or the ache medicine, Ultram (tramadol), but can happen with taking Zoloft alone, as effectively.

A few of the signs and symptoms of this situation are agitation, confusion, an excessive coronary heart rate,  inflexible muscle groups and/or coordination issues, fluctuating blood strain, tremor, and gastrointestinal issues like diarrhea.

To be proactive in avoiding this rare syndrome from occurring, be sure to tell your doctor all the medications you are taking, including any over-the-counter drugs or supplements.

Increased Risk of Bleeding

There is an increased chance of bleeding when taking Zoloft along with medications that block platelets or medications that thin your blood. Examples embrace aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and Coumadin (warfarin).

Please notify your doctor right away of any bleeding events like nosebleeds or increased bruising. Search medical attention instantly if you happen to discover extra severe bleeding occasions like blood in your stool.

Mania or Hypomania

Zoloft can trigger a hypomanic or manic episode in a person with bipolar disorder. Remember to tell your doctor if you have ever been diagnosed or suspected of having bipolar disorder, or have a family history of it.

Low Sodium Levels

Low sodium levels in the bloodstream (called hyponatremia) may occur with Zoloft, in addition to other SSRIs.

Signs and symptoms of hyponatremia include:

  • Headache
  • Problems concentrating
  • Memory difficulties
  • Confusion
  • Weakness
  • Unsteadiness and potentially falling

In more severe cases, hyponatremia can lead to seizures, hallucinations, and death. It is necessary for your physician to observe you carefully whereas taking your antidepressant. He might need to examine your sodium level after you’ve been on Zoloft.

Allergic Reaction

It is uncommon. When you take Zoloft it hardly ever can develop signs or symptoms of an allergic response like a rash, hives, swelling, or problems breathing, contact your physician instantly.


Zoloft is indicated as pregnancy category-C medicine, so you should make your doctor aware of the fact that you are pregnant. Use of Zoloft in the third trimester may cause a baby with persistent pulmonary hypertension which can cause breathing problems. In addition, third-trimester use of Zoloft may cause neonatal withdrawal symptoms like temperature instability, feeding problems, and constant crying.

Final words

However, some women may need to continue taking Zoloft during pregnancy because of the benefit of treating their illness outweighs the potential risks. Overall, this choice requires a cautious and considerate dialogue with each an obstetrician and psychological well being skilled.

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